2020 Dec 14;15(1):93. doi: 10.1186/s13011-020-00334-x. Please enable it to take advantage of the complete set of features! Individuals with a history of a substance use disorder (SUD) are at greater risk of abusing benzodiazepines [9, 10]. Benzodiazepine misuse is a worldwide public health concern that is associated with a number of concerning consequences. Aas CF, Vold JH, Gjestad R, Skurtveit S, Lim AG, Gjerde KV, Løberg EM, Johansson KA, Fadnes LT; INTRO-HCV Study Group. OBJECTIVES: We aimed to identify and appraise studies examining benzodiazepine use and survival in adults with cancer, to investigate the relationship and context of use. However, relatively little attention has been paid to this emergent problem. Worldwide rates of misuse appear to be similar to those reported in the U.S. Factors associated with misuse include other substance use, receipt of a benzodiazepine prescription, and psychiatric symptoms and disorders. Moreover, misuse is associated with myriad poor outcomes, including mortality, HIV/HCV risk behaviors, poor self-reported quality of life, criminality, and continued substance use during treatment. Among benzodiazepine users, benzodiazepine use disorders have been reported at 1.5%, but benzodiazepine misuse is more common at 17.1% . Prevention and treatment information (HHS). 3. Note: Records could be excluded…, National Library of Medicine doi: 10.4088/JCP.18m12174. The search identified 1970 publications, and 351 articles were eligible for data extraction and inclusion. Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage. Swiss Med Wkly. A total of 981,133 (in the systematic review) and 980,860 (in the meta‐analysis) adults or elderly individuals. Note: Records could be excluded for multiple reasons. After a systematic literature search we did not find any studies that could answer this question. Benzodiazepine use and aggressive behaviour: A systematic review Bonnie Albrecht, Petra K Staiger, Kate Hall, Peter Miller, David Best, and Dan I Lubman Australian & New Zealand Journal of Psychiatry 2014 48 : 12 , 1096-1114 A Systematic Review of Opioid and Benzodiazepine Misuse in Older Adults. Bethesda, MD 20894, Copyright Eligibility criteria Wenn Benzodiazepine mehr als ein paar Wochen angewendet werden, ist es oft schwierig sie abzusetzen, da sich eine körperliche und psychische Abhängigkeit entwickelt hat. Overall, outcome measures were similar between each of the benzodiazepines evaluated in the treatment of anxiety disorders. Recherchedatum. Eligibility criteria included human studies that focused on the prevalence, trends, correlates, motives, patterns, sources, and consequences of benzodiazepine misuse. BibTeX (win & mac)Download; EndNote (tagged)Download; EndNote 8 (xml)Download; RefWorks Tagged (win & mac)Download; RIS … Study characteristics. 2018 Oct 16;79(6):18m12174. Please enable it to take advantage of the complete set of features! A systematic literature search of clinical articles was conducted on April 21, 2015 in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines , . This systematic review and meta-analysis aims at providing data on the prevalence of benzodiazepines and benzodiazepine-related drugs in the peripartum period. Benzodiazepine usage rates are higher for older patients than for younger adults, and the elderly constitute the largest group of long-term users. doi: 10.3205/000178. Types of evidence: Type A. Would you like email updates of new search results? Bethesda, MD 20894, Copyright However, relatively little attention has been paid to this emergent problem. Results: K23 DA035297/DA/NIDA NIH HHS/United States, T32 AA018108/AA/NIAAA NIH HHS/United States. Epub 2016 Jun 7. FOIA Substance use and symptoms of mental health disorders: a prospective cohort of patients with severe substance use disorders in Norway. The use of benzodiazepines (BZDs) in the treatment of posttraumatic stress disorder (PTSD) is both common and controversial. [Systematic review of the side effects of benzodiazepines] Ned Tijdschr Geneeskd. 2005;22(9):749-65. doi: 10.2165/00002512-200522090-00004. MMWR Surveill Summ. Careers. There is almost no development of tolerance for these cognitive problems.- Tailored patient education letters for ceasing benzodiazepine use are more effective than the standard letters. COVID-19 is an emerging, rapidly evolving situation. Benzodiazepine misuse is a growing public health problem, with increases in benzodiazepine-related overdose deaths and emergency room visits in recent years. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2013 Jan 17;143:w13745. METHODS: Systematic review of the international literature prepared according to preferred reporting items for systematic reviews. Benzodiazepine use in seizure emergencies: A systematic review Epilepsy Behav. Das Ziel dieses Reviews war, die Wirkung und Sicherheit von Medikamenten zu beurteilen, die das Absetzen von Benzodiazepinen bei chronischem Gebrauch erleichtern sollen. 8600 Rockville Pike Privacy, Help Br Med J 1980; 280 :910 . Die Evidenz ist auf … PDF | On Nov 1, 1980, T R Einarson published Systematic review of the benzodiazepines | Find, read and cite all the research you need on ResearchGate alesha.smith@uq.edu.au BACKGROUND: Benzodiazepines are often used on a long term basis in the elderly to treat various psychological disorders including sleep disorders, some neurological … 2015 Nov;105(11):e29-49. 2016 Nov;24(11):949-963. doi: 10.1016/j.jagp.2016.06.003. J Clin Psychiatry. Prevalence and correlates of nonmedical use of prescription drugs (NMUPD) among Young adults experiencing homelessness in seven cities across the United States. Applicability and generalizability of palliative interventions for dyspnoea: one size fits all, some or none? Privacy, Help Clonazepam has the most evidence to support its use and is relatively less likely to lead to abuse because of its longer half-life, but caution is still needed given … Background: Benzodiazepine misuse is a growing public health problem, with increases in benzodiazepine-related overdose deaths and emergency room visits in recent years. Print 2013. benzodiazepine. 2015 Oct 16;64(9):1-14. doi: 10.15585/mmwr.ss6409a1. Prevalence and Correlates of Benzodiazepine Use, Misuse, and Use Disorders Among Adults in the United States. Benzodiazepine misuse encompasses heterogeneous presentations of motives, patterns, and sources. Electronic address: SHAUT@montefiore.org. The primary outcome was BZRA use, classified as discontinuation or reduction by ≥ 25%. 2016 Oct;63:109-117. doi: 10.1016/j.yebeh.2016.07.018. In 2017, benzodiazepines and other tranquilizers were the third most commonly misused illicit or prescription drug in the U.S. (approximately 2.2% of the population). Siriwardena AN, Qureshi Z, Gibson S, Collier S, Latham M. Allain H, Bentué-Ferrer D, Polard E, Akwa Y, Patat A. Methods. Methods: 2021 Feb 16. doi: 10.1007/s00213-021-05793-z. Benefits and risks of benzodiazepines and Z-drugs: comparison of perceptions of GPs and community pharmacists in Germany. See this image and copyright information in PMC. Measurements and Main Results. Perceptions of German GPs on benefits and risks of benzodiazepines and Z-drugs. A Systematic Review and Meta-Synthesis of Patients' Experiences and Perceptions of Seeking and Using Benzodiazepines and Z-Drugs: Towards Safer Prescribing. 2021 Jan 14;14:616298. doi: 10.3389/fnins.2020.616298. 2021 Jan 14;11:608887. doi: 10.3389/fphar.2020.608887. Conclusions: Ger Med Sci. Findings from the present review have implications for identifying subgroups who could benefit from prevention and treatment efforts, critical points for intervention, and treatment targets. Although BZDs are prescribed to 30% to 74% of patients … Comparison of Benzodiazepine Agents.....6 Disease Overview ... anxiety, the benzodiazepines were compared in one systematic review and eleven comparative efficacy trials. Unable to load your collection due to an error, Unable to load your delegates due to an error. FOIA Subst Abuse Treat Prev Policy. 2017;161:D1052. Systematic review and meta‐analysis of 12 prospective and retrospective cohort studies and case‐control studies. Authors Sheryl R Haut 1 , Syndi Seinfeld 2 , John Pellock 2 Affiliations 1 Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York City, NY, USA. 2021 Feb 27;16(1):20. doi: 10.1186/s13011-021-00354-1. Evidence-based treatments for PTSD should be favored over BZDs. COVID-19 is an emerging, rapidly evolving situation. Up to 1 million people in the UK are currently long-term prescribed benzodiazepine users. The aim of this systematic review was to critically evaluate the success of interventions used to reduce benzodiazepines and ‘Z-drug’ use, and the impact of these interventions on clinical outcomes in older adults. Paulozzi LJ, Strickler GK, Kreiner PW, Koris CM; Centers for Disease Control and Prevention (CDC). Flow diagram of records identified, screened, and included. Author information: (1)University of Queensland, School of Pharmacy, Brisbane, Queensland, 4072, Australia. Different dose-tapering schemes have comparable success rates (on average 50%). Accessibility Benzodiazepines; Nonmedical prescription drug use; Prescription drug misuse; Sedatives; Tranquilizers. C.B. Background: PubMed and PsychINFO databases were searched through February 2019 for peer-reviewed publications on benzodiazepine misuse (e.g., use without a prescription; at a higher frequency or dose than prescribed). 1 Surveys of general practices show that there are over 180 long-term prescribed users per general practice. Controlled Substance Prescribing Patterns--Prescription Behavior Surveillance System, Eight States, 2013. Benzodiazepine (BNZ) use is associated with increased hip fracture rate, consequently Z-drugs are fast becoming the physician’s hypnotic prescription of choice yet data on their use is limited. eCollection 2020. We identified 38 randomised controlled trials involving 2543 participants who had either been treated for more than two months with benzodiazepines, or who had … The views expressed in this article are those of the authors solely and do not necessarily represent the views, policies and decisions of WHO. Patient. Blanco C, Han B, Jones CM, Johnson K, Compton WM. doi: 10.2105/AJPH.2015.302843. doi: 10.4414/smw.2013.13745. Sirdifield C, Chipchase SY, Owen S, Siriwardena AN. Careers. ched independently by two reviewers for studies in adult (former) ICU patients, reporting benzodiazepine use, and neuropsychiatric outcomes of delirium, posttraumatic stress disorder, depression, anxiety, and cognitive dysfunction. Different benzodiazepines present similar risks of falls and fractures; higher doses present a higher risk, and Z-drugs are no safer.- In comparison with placebo, benzodiazepines and Z-drugs soon cause cognitive problems, even at low doses and in drugs with a short half-life. Systematic review of randomized controlled trials of brief interventions in primary care settings aimed at reducing or discontinuing long‐term BZRA use in adults taking BZRAs for ≥ 3 months. Smith AJ(1), Tett SE. This systematic review was financially supported by the Department of Mental Health and Substance Abuse, World Health Organization (WHO), Geneva, Switzerland. Front Neurosci. Online ahead of print. This site needs JavaScript to work properly. Participants. Our review therefore supports the … In August 2016, we found eight studies. All randomised trials comparing combined psychotherapy and benzodiazepine for panic disorder with either therapy alone were identified by comprehensive … Drugs Aging. 2017 Feb;10(1):1-15. doi: 10.1007/s40271-016-0182-z. Epub 2016 Sep 6. 2.1. Postural instability and consequent falls and hip fractures associated with use of hypnotics in the elderly: a comparative review. This review aimed to assess the effect and safety of medications to facilitate benzodiazepine discontinuation in chronic benzodiazepine users. Augmentation with cognitive behavioural therapy is effective for dose reduction.- It is therefore important to carefully consider the use of benzodiazepines before using them. The results of this systematic review suggest that BZDs should be considered relatively contraindicated for patients with PTSD or recent trauma. Epub 2019 May 14. Systematic review of the benzodiazepines. Extensive clinical experience suggests, however, that when the drugs are used in low therapeutic doses, the side effects, when present, are mild and reversible when the drugs are discontinued (see side effects below). Berro LF, Overton JS, Reeves-Darby JA, Rowlett JK. - Benzodiazepines are used frequently, despite the risk of severe side effects.- The Generic module 'Side effects; prevention, monitoring and treatment of side effects of drugs for psychiatric disorders' will be published soon. Front Pharmacol. 8600 Rockville Pike The present systematic review aims to examine its efficacy compared with either monotherapy alone. Conclusion: Benzodiazepine use for subjective tinnitus does not have a robust evidence base. 2 and 3). Looking for Novelty in an "Old" Receptor: Recent Advances Toward Our Understanding of GABA. We systematically reviewed epidemiological studies on benzodiazepine misuse to identify key findings, limitations, and future directions for research. More like this. We systematically reviewed epidemiological studies on benzodiazepine misuse to identify key findings, limitations, and future directions for research. 2 Despite repeated recommendations to limit benzodiazepines to short-term use (2–4 weeks), doctors in the UK and worldwide are still prescribing them for months or years. Maree RD, Marcum ZA, Saghafi E, Weiner DK, Karp JF. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Am J Public Health. As part of this process, a systematic review was undertaken to determine the existing evidence of mortality risk for extra-medical illicit benzodiazepine use-that is, use outside the advice of a doctor or allied health professional. eCollection 2013. By undertaking this systematic review and meta-analysis of perioperative benzodiazepine use, we will summarise the state of knowledge and identify important gaps that need to be addressed through the conduct of randomised controlled trials. This contains recommendations for reduction in the risk for falls and fractures, cognitive problems and dependency related to the use of benzodiazepines or Z-drugs (zopiclone, zolpidem).- Prescribing physicians and pharmacists are compulsorily required to provide extensive information to patients on the anticipated effects and side effects of benzodiazepines, and on the limited prescription period.- A lot of information has become available from systematic literature reviews by the Benzodiazepines working group. This systematic review, based on 41 register-based studies, provides a comprehensive understanding of long-term BZD use in real world, the definitions of long-term BZD use, typical long-term use patterns, prevalence and characteristics associated with long-term use (Tables 2–5, Figs. We compared the risk of hip fracture associated with Z-drugs and BNZ medications, respectively, and examined if this risk varied with longer-term use. This systematic review aimed to summarize the effects of concurrent prescription of benzodiazepines among people who receive opioid maintenance treatment. Impact of clinical and sociodemographic factors on fatigue among patients with substance use disorder: a cohort study from Norway for the period 2016-2020. The efficacy of combined psychotherapy and benzodiazepine treatment for panic disorder is still unclear despite its widespread use. eCollection 2020. Vereniging Nederlands Tijdschrift voor Geneeskunde. In this updated systematic review we aimed to determine whether benzodiazepines relieved breathlessness in adults with advanced disease. National Library of Medicine Flow diagram of records identified, screened, and included. The evidence is current to October 2017. GPs' attitudes to benzodiazepine and 'Z-drug' prescribing: a barrier to implementation of evidence and guidance on hypnotics. Vold JH, Gjestad R, Aas CF, Chalabianloo F, Skurtveit S, Løberg EM, Johansson KA, Fadnes LT; INTRO-HCV Study Group. Benzodiazepines are effective medicines for insomnia and anxiety but are commonly used beyond recommended treatment time frames, which may lead to adverse drug events. Clipboard, Search History, and several other advanced features are temporarily unavailable. The aim of this systematic review was to identify, appraise, and synthesize studies assessing benzodiazepine use and survival in patients with cancer and to explore this relationship and how this relates to the context of use, for example, in palliative sedation or in the management of specific symptoms such as dyspnea, anxiety, or restlessness. We studied the use of these prescription drugs before, during and after pregnancy, in the different trimesters, in various countries and we examined prevalence rates over time. The search was not limited by publication date or publisher and was filtered for English language. Am J Geriatr Psychiatry. 2013 Jul 18;11:Doc10. Psychopharmacology (Berl). Brief interventions targeting long‐term benzodiazepine and Z‐drug use in primary care: a systematic review and meta‐analysis Published in: Addiction, February 2020 DOI: 10.1111/add.14981: Pubmed ID: 31985127. Current evidence shows that benzodiazepine withdrawal is feasible in the older population, but withdrawal rates vary according to the type of intervention. Prevention and treatment information (HHS). Results: Of 4,932 reviewed reports, 15 were included in this systematic review. Accessibility Worldwide Prevalence and Trends in Unintentional Drug Overdose: A Systematic Review of the Literature. Priorities of Care: Priority 5: Plan and do . Abstract. Barman-Adhikari A, Hsu HT, Brydon D, Petering R, Santa Maria D, Narendorf S, Shelton J, Bender K, Ferguson K. Drug Alcohol Depend. Subst Abuse Treat Prev Policy. Search date . Would you like email updates of new search results? This site needs JavaScript to work properly. Unable to load your collection due to an error, Unable to load your delegates due to an error. [Article in Dutch] Authors A Seldenrijk 1 , R Vis, M Henstra, K Ho Pian, D van Grootheest, T Salomons, F Overmeire, M de Boer, T Scheers, R Doornebal-Bakker, H G Ruhé, C H Vinkers. 2019 Jul 1;200:153-160. doi: 10.1016/j.drugalcdep.2019.03.015. Benzodiazepines caused more side effects such as drowsiness or somnolence when compared to placebo but caused less side effects when compared to morphine. Committee on the Review of Medicines. Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines. A non-systematic review of interventions tried in the last 20 years. Dornellas APS, Macedo GC, McFarland MH, Gómez-A A, O'Buckley TK, Da Cunha C, Morrow AL, Robinson DL. Four electronic databases were searched: PubMed, EMBASE, PsycINFO and CENTRAL. Keywords: Copyright © 2019 Elsevier B.V. All rights reserved. As the benefits and sustainability of these interventions are unclear, further studies should be conducted to assess this.